Dum et al. explored which cortical areas may be involved in cognitive control of the stress response by injecting rabies virus into the adrenal medulla — which secretes hormones as part of this response — of non-human primates and assessing its retrograde transport. Two main cortical networks were linked via multisynaptic connections to the adrenal medulla: one comprised cortical motor areas in the frontal lobe and some somatosensory cortical areas, and the other comprised medial prefrontal cortex areas, including some involved in higher cognition and affect. Thus, various cortical regions may influence adrenal medulla function.