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Innate fear-like responses are thought to involve the amygdala, but here a tetra-synaptic pathway is identified that mediates odour-evoked innate fear in mice.
One of the long-term sequelae associated with SARS-CoV-2 infection is ‘brain fog’, which is shown in this study to be linked to systemic inflammation and leakiness of the blood–brain barrier.
Many brain areas support complex language processing behaviours. In this Review, Fedorenko et al. disentangle the ‘core’ language system as functionally distinct from the perceptual and motor brain areas and knowledge and reasoning systems it closely interacts with during language comprehension and production.
Pathological compulsive behaviour is a potential transdiagnostic symptom of several neuropsychiatric disorders. In this Review, Robbins et al. examine the psychological basis of compulsions and compulsivity and their underlying neural circuitry, focused on fronto-striatal systems implicated in goal-directed behaviour and habits.
There is a pressing need for drugs that effectively control pharmaco-resistant seizures and prevent their generation. In this Review, Vezzani and co-workers discuss the interconnected roles of mTOR signalling and neuroinflammatory processes in epileptogenesis, and how targeting these pathways might prove useful therapeutically.
Selective vulnerability of particular neuronal cell types is a characteristic of neurodegenerative diseases. Martin Kampmann explores our current understanding of the cellular and molecular mechanisms that lead to selective vulnerability in different diseases.
