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The tissue culture bottleneck for gene editing in plants can be overcome by modifying somatic cells in whole plants and inducing the formation of shoot meristems.
Infection with RNA viruses of the Flaviviridae family leads to changes in the methylation of host mRNAs that are driven by induction of innate immunity and endoplasmic reticulum stress
Catalytically inactive caspase 8 can activate pyroptosis when apoptosis and necroptosis are blocked, a potential line of defence against viruses that inhibit cell death.
Nutrient status is uncoupled from the control of autophagy during mitosis through a switch from mTORC1- to CDK1-mediated inhibition of autophagy regulators.
Compounds that tether toxic proteins with polyglutamine expansions to autophagosomes promote their autophagic clearance and might, in principle, be suitable for the treatment of associated neurodegenerative diseases.
Roop Mallik argues for the importance of considering the impact that membrane lipids have on motors, and the dynamics of the membrane–motor interface, in studies of cytoskeletal motors.