News & Comment

Age-dependent decline in muscle stem cell function is due to increased fibroblast growth factor (FGF) signalling from the niche.

A conserved mechanism protects against heatstroke-mediated necrosis and neurodegeneration.

Taz1 is recruited to telomeric sequences and regulates replication timing in fission yeast.

Sensing of nodal flow for symmetry breaking occurs via PKD2 localized at cilia.

This study describes a new class of lncRNAs flanked by snoRNAs and shows that they have a role in splicing.

The sequence-specific transcription factors PAX3 and PAX9 promote heterochromatin formation.

The Hippo pathway has been implicated in the regulation of mitochondrial fusion and the generation of reactive oxygen species.

Set2 methylation of Lys36 and the recruitment of chromatin remodellers represses histone exchange which limits the incorporation of acetylated histones in coding regions, thereby maintaining chromatin integrity and accurate transcription initiation.

Active WNTs are secreted on exosomes.

WASP can substitute for SCAR function during cell protrusion inDictyostelium discoideum.

Clathrin heavy chain 17 promotes centrosome maturation at the onset of mitosis.

Slow-cycling stem cells and more rapidly cycling progenitors contribute to skin maintenance.

The DUB POH1 and the E3 ligases TRIP12 and UBR5 regulate ubiquitin signalling during the DNA damage response.

GPCRs regulate YAP and TAZ activity through LATS1 and LATS2.

Two distinct regions in ORC1 control centrosome copy number and DNA replication.

The transition from meiosis to mitosis in mouse embryos occurs gradually.

Uncapped telomeres signal a block in mitotic entry through two distinct mechanisms.

RAP2A provides a link between apical polarity cues and cytoskeletal regulators during brush border formation.

Fluorescence-based sensors allow the study of ubiquitin chainsin vivo.