Table of contents
April 2008 Vol 9 No 4
From the editors
p263 | doi:10.1038/nrm2387
Research Highlights
Cancer biology: Warburg effect revisited | PDF (145 KB)
p264 | doi:10.1038/nrm2384
Membrane trafficking: Ceramide buds in | PDF (147 KB)
p265 | doi:10.1038/nrm2381
Nuclear transport: Signalling and transport converge | PDF (201 KB)
p265 | doi:10.1038/nrm2386
Membrane trafficking: GTPases stack up | PDF (173 KB)
p266 | doi:10.1038/nrm2365
Chromosome biology: Transcription at the edge | PDF (146 KB)
p266 | doi:10.1038/nrm2377
Gene expression: Translation in real time | PDF (88 KB)
p266 | doi:10.1038/nrm2382
In brief
Cytoskeleton | Stem cells | RNA silencing | PDF (99 KB)
p267 | doi:10.1038/nrm2380
Protein secretion: An unconventional route | PDF (195 KB)
p268 | doi:10.1038/nrm2367
Gene expression: Cohesin branches out | PDF (369 KB)
p268 | doi:10.1038/nrm2371
Technology Watch
Ghost fish | Fluorescent cycling | PDF (149 KB)
p268 | doi:10.1038/nrm2372
Cell division: Inn a pinch | PDF (129 KB)
p269 | doi:10.1038/nrm2383
An Interview With...
Alex Rich | PDF (233 KB)
p270 | doi:10.1038/nrm2373
Reviews
Exiting the Golgi complex
Maria Antonietta De Matteis & Alberto Luini
p273 | doi:10.1038/nrm2378
The trans-Golgi network (TGN) is a major sorting centre for lipids and proteins that lies at the crossroads of endocytic and exocytic pathways. Recent studies have started to elucidate the molecular machineries that function in sorting and trafficking at the TGN.
The role of oxygen availability in embryonic development and stem cell function
M. Celeste Simon & Brian Keith
p285 | doi:10.1038/nrm2354
Oxygen is required for the survival of most organisms. Recent advances show that it is not only important for the promotion of cellular bioenergetics and metabolism, but also that it is an essential signal that regulates cell fate during embryonic development and in stem cells.
Regulation of DNA repair throughout the cell cycle
Dana Branzei & Marco Foiani
p297 | doi:10.1038/nrm2351
Recent studies have provided insights into the mechanisms that regulate DNA repair in specific cell-cycle phases and the pathways that ensure cell-cycle progression or arrest in normal and cancerous cells. Understanding how DNA repair is modulated during the cell cycle has important applications.
Tracking the ends: a dynamic protein network controls the fate of microtubule tips
Anna Akhmanova & Michel O. Steinmetz
p309 | doi:10.1038/nrm2369
How do cytoskeletal components interact to control cellular processes? At the growing microtubule plus ends, microtubule plus-end tracking proteins (+TIPs) regulate different aspects of cell architecture by controlling microtubule dynamics, microtubule interactions with cellular structures and signalling factors, and forces exerted on microtubule networks.
How membrane proteins sense voltage
Francisco Bezanilla
p323 | doi:10.1038/nrm2376
Recent studies have provided insights into the mechanisms of voltage sensing and have identified new voltage-dependent proteins. Characterizing the general features of voltage sensors might lead to the discovery of further membrane proteins that are regulated by voltage.
Perspectives
Science and society
Childhood of a phoenix: modern biology in Eastern and South-Eastern Europe
Bojan Zagrovic & Ivan Dikic
p333 | doi:10.1038/nrm2368
In the shadow of societal upheaval and transformation, Eastern and South-Eastern European countries have been undergoing major reforms of their scientific and academic landscapes. Although the reforms have been slow, the success of several molecular biology institutes has highlighted what can be achieved.
Opinion
Multifunctional deadenylase complexes diversify mRNA control
Aaron C. Goldstrohm & Marvin Wickens
p337 | doi:10.1038/nrm2370
Deadenylases shorten mRNA poly(A) tails and thereby regulate mRNA translation and decay. Recent studies have shown that these factors form different complexes. The recruitment of multifunctional deadenylase complexes to target mRNAs provides a unique node to control mRNA translation and decay.
