Perspectives
Nature Reviews Molecular Cell Biology 7, 690-696 (September 2006) | doi:10.1038/nrm1979
Innovation: High-throughput fluorescence microscopy for systems biology
Rainer Pepperkok & Jan Ellenberg1 About the authors
Abstract
In this post-genomic era, we need to define gene function on a genome-wide scale for model organisms and humans. The fundamental unit of biological processes is the cell. Among the most powerful tools to assay such processes in the physiological context of intact living cells are fluorescence microscopy and related imaging techniques. To enable these techniques to be applied to functional genomics experiments, fluorescence microscopy is making the transition to a quantitative and high-throughput technology.
Author affiliations
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Rainer Pepperkok is at the Cell Biology/Biophysics Unit and Jan Ellenberg is at the Gene Expression and Cell Biology/Biophysics Units, in the European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.
Email: rainer.pepperkok@embl.de; Email: jan.ellenberg@embl.de
Published online 19 July 2006
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