Review
Nature Reviews Molecular Cell Biology 5, 481-492 (June 2004) | doi:10.1038/nrm1402
Dynamic Microtubules Lead the Way for Spindle Positioning
Chad G. Pearson1 & Kerry Bloom1 About the authors
Abstract
Coordination between the asymmetric partitioning of cell-fate determinants and equal partitioning of genetic material is crucial to the generation of diverse cell types in a developing organism, and to the maintenance of genomic integrity. The emerging model is of a highly organized and dynamic cellular landscape, the form of which is defined by polarized signals within the cell. Cytoskeletal elements are necessary to generate this landscape and to provide motive forces for proper spindle positioning. These forces are generated by interactions between microtubules and the cell cortex.
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Author affiliations
- Department of Biology, University of North Carolina at Chapel Hill, Fordham Hall Room 622, Chapel Hill, North Carolina 27599-3280.
Correspondence to: Kerry Bloom1 Email: kbloom@email.unc.edu
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