There is much interest in defining the secretory transport vesicles that sort cargo at the Golgi for trafficking to different regions of the plasma membrane. Wakana et al. have found a new class of transport carrier that forms in the trans-Golgi network (TGN) and then targets the cell surface in HeLa cells. These carriers, which they term CARTS (carriers of the TGN to the cell surface), require protein kinase D for their biogenesis and myosin II for their movement. They carry a specific set of cargo proteins and are distinct from previously characterized carriers that transport large cargo such as the VSV-G glycoprotein. Characterization of CARTS should therefore provide new understanding of cargo sorting for transport to the cell surface from the Golgi.