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Recent studies show that antigenic peptides are derived from the translation of precursor mRNAs. Robin Fåhraeus argues that it is therefore time to re-evaluate nuclear translation and its interesting implications.
Quality control of misfolded glycosylphosphatidylinositol-anchored proteins (GPI-APs) does not occur through ER-associated degradation, as the lipid anchor precludes retrotranslocation across the ER membrane. Instead, different organisms have developed distinct solutions to prevent the accumulation of misfolded GPI-APs.
Numerous databases collate data on long non-coding RNAs (lncRNAs); Ma and Zhang describe their range and discuss their contribution to lncRNA research.
In this Comment, the authors draw attention to non-apoptotic roles of BCL-2 proteins in the regulation of cellular senescence and voice the need for caution in using BCL-2 inhibitors as senolytics.
Fleming and Burrows discuss similarities between a gene-regulating DNA modification and a mutagenic one, which share a common intermediate when removed through base excision repair.
In response to tissue damage in adults, embryonic gene expression programmes are reactivated to enhance repair. Hassan Fazilaty describes a correlation between damage extent and how early in embryogenesis the restored expression programme is.
Oded Rechavi and Pavel Tomancak suggest a new approach to ascribing authorship in scientific papers that specifies who thought of each idea, who ran each experiment and who analysed the data.