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Rana et al. show that in the gut epithelium, gasdermin B has an inherent, non-pyroptotic function, supporting the maintenance of the epithelial barrier when challenged with inflammatory damage.
Mike Henne discusses the pioneering work of Jean Vance, which revealed that mitochonodria-associated membranes (MAMs) are sites for inter-organelle phospholipid exchange and step-wise synthesis reactions.
Prior to introduction of the first DNA–protein structure, Ned Seeman et al. correctly conceived how proteins recognize specific sequences in double-helix nucleic acids.
X chromosome inactivation in mammals involves chromosome-wide gene silencing at one X chromosome in cells of females, a process that requires complex spatiotemporal regulation. Recent findings provide new insights into the mechanisms and dynamics of X chromosome inactivation and the accompanying 3D reshaping of the chromosome.
Aneuploidy affects organisms from early development through to aging and is a cause of pregnancy loss and cancer. Recent studies have increased our understanding of its mechanisms and how it can be both beneficial and detrimental to cells and organisms, depending on the karyotype and external cues. These insights shed light on its roles in human pathogenesis and on genome evolution.
