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Dysregulated inflammasome activation is linked to numerous inflammatory disorders and is therefore tightly regulated. In this Review, the authors discuss the latest insights into the activation and assembly mechanisms of inflammasomes, the structure of distinct inflammasome complexes and the mechanisms that regulate inflammasome signalling.
Structural and functional similarities between the cytolytic synapses formed by CD8+T cells and primary cilia are shedding new light on the mechanisms and order of events of synapse formation.
Here, the authors discuss the role of C-type lectin receptor signalling pathways in the control of T helper cell differentiation and examine how these receptors and pathways can be harnessed for vaccine strategies.
A broad and practical overview for applying computational techniques to analyse, visualize and interpret high-dimensional data from flow cytometry. Computational flow cytometry improves reproducibility, allows automated identification of cell populations and biomarkers, as well as enables predictive modelling of clinical correlates and cell development pathways.