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Viral hepatitis

Treating hepatitis C in children: an open horizon

Most children with chronic hepatitis C have minimal liver disease before adulthood, but could be at risk of progression to cirrhosis and hepatocellular carcinoma because of persistent virus replication. The results of the first controlled trial with PEG-IFN-α2a plus ribavirin are a step towards an appropriate treatment for these children.

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References

  1. Alter, M. J. et al. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N. Engl. J. Med. 341, 556–562 (1999).

    Article  CAS  PubMed  Google Scholar 

  2. Bortolotti, F. et al. Epidemiological profile of 806 Italian children with hepatitis C virus infection over a 15-year period. J. Hepatol. 46, 783–790 (2007).

    Article  PubMed  Google Scholar 

  3. Schwarz, K. B. et al. The combination of ribavirin and peginterferon is superior to peginterferon and placebo for children and adolescents with chronic hepatitis C. Gastroenterology 140, 450–458 (2011).

    Article  CAS  PubMed  Google Scholar 

  4. Hu, J., Doucette, K., Hartling, L., Tjosvold, L. & Robinson, J. Treatment of hepatitis C in children: a systematic review. PLoS ONE 5, e11542 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Wirth, S. et al. High sustained virologic response rates in children with chronic hepatitis C receiving peginterferon alpha-2b plus ribavirin. J. Hepatol. 52, 501–507 (2010).

    Article  CAS  PubMed  Google Scholar 

  6. Ghany, M. G. et al. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 49, 1335–1374 (2009).

    CAS  PubMed  Google Scholar 

  7. Bortolotti, F. et al. Long-term course of chronic hepatitis C in children: from viral clearance to end-stage liver disease. Gastroenterology 134, 1900–1907 (2008).

    Article  PubMed  Google Scholar 

  8. Goodman, Z. D. et al. Pathology of chronic hepatitis C in children: liver biopsy findings in the Peds-C Trial. Hepatology 47, 836–843 (2008).

    Article  PubMed  Google Scholar 

  9. Guido, M. et al. Fibrosis in chronic hepatitis C acquired in infancy: is it only a matter of time? Am. J. Gastroenterol. 98, 660–663 (2003).

    Article  PubMed  Google Scholar 

  10. Balagopal, A., Thomas, D. L. & Thio, C. L. IL28B and the control of hepatitis C virus infection. Gastroenterology 139, 1865–1876 (2010).

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Maria Guido.

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Guido, M., Bortolotti, F. Treating hepatitis C in children: an open horizon. Nat Rev Gastroenterol Hepatol 8, 247–248 (2011). https://doi.org/10.1038/nrgastro.2011.61

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