Abstract

The rapid accumulation of complete genomic sequences offers the opportunity to carry out an analysis of inter- and intra-individual genome variation within a species on a routine basis. Sequencing whole genomes requires resources that are currently beyond those of a single laboratory and therefore it is not a practical approach for resequencing hundreds of individual genomes. DNA microarrays present an alternative way to study differences between closely related genomes. Advances in microarray-based approaches have enabled the main forms of genomic variation (amplifications, deletions, insertions, rearrangements and base-pair changes) to be detected using techniques that are readily performed in individual laboratories using simple experimental approaches.

Author affiliations

1. Lewis–Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, New Jersey, 08544, USA.
   Email: dgresham@genomics.princeton.edu; Email: maitreya@princeton.edu; Email: botstein@genomics.princeton.edu
2. Department of Molecular Biology, Carl Icahn Laboratory, Princeton University, Princeton, New Jersey, 08544, USA.

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