Table of contents
November 2007 Vol 8 No 11
From the editors
p821 | doi:10.1038/nrg2232
Research Highlights
Technology: A new tool for analysing structural variation | PDF (268 KB)
p822 | doi:10.1038/nrg2230
Cancer genetics: Networks uncover new cancer susceptibility suspect | PDF (138 KB)
p823 | doi:10.1038/nrg2229
In brief
| PDF (117 KB)
p823 | doi:10.1038/nrg2265
Association studies: Dog genes mapped at a SNP | PDF (300 KB)
p824 | doi:10.1038/nrg2233
Development: Mutual collaboration | PDF (185 KB)
p824 | doi:10.1038/nrg2234
In brief
| PDF (116 KB)
p824 | doi:10.1038/nrg2266
Chromatin: Remodellers are more than just muscle | PDF (364 KB)
p825 | doi:10.1038/nrg2231
Genetic screens: Epistasis on the double | PDF (661 KB)
p826 | doi:10.1038/nrg2221
Genomics: HapMap Phase II unveiled | PDF (323 KB)
p826 | doi:10.1038/nrg2235
Gene regulation: The many paths to coexpression | PDF (361 KB)
p827 | doi:10.1038/nrg2228
Ethics watch
Carrier testing in minors: conflicting views | PDF (207 KB)
p828 | doi:10.1038/nrg2222
Progress
Histone lysine demethylases: emerging roles in development, physiology and disease
Yang Shi
p829 | doi:10.1038/nrg2218
Functions of histone lysine demethylases in a range of developmental and physiological processes are rapidly being uncovered, as are the roles of these enzymes in disease. Histone demethylases also provide a promising new route towards the therapeutic targeting of epigenetic regulators.
Reviews
Genetic links between diet and lifespan: shared mechanisms from yeast to humans
Nicholas A. Bishop & Leonard Guarente
p835 | doi:10.1038/nrg2188
Recent studies in yeast, invertebrates and mammals have begun to solve the puzzle of how dietary restriction results in increased longevity. An increased knowledge of the underlying pathways promises to provide new directions for treating ageing-related diseases in humans.
Which evolutionary processes influence natural genetic variation for phenotypic traits?
Thomas Mitchell-Olds, John H. Willis & David B. Goldstein
p845 | doi:10.1038/nrg2207
A combination of ecological, population genetic and molecular studies has stimulated progress in understanding the forces that shape natural phenotypic variation. Technical advances that allow fitness differences to be linked to individual polymorphisms now promise rapid progress in this field.
Recent and ongoing selection in the human genome
Rasmus Nielsen, Ines Hellmann, Melissa Hubisz, Carlos Bustamante & Andrew G. Clark
p857 | doi:10.1038/nrg2187
Identifying regions of the human genome that have been subject to selection is key to understanding our evolution, and provides insights into the genetic basis of disease. However, important caveats require consideration when interpreting the results of attempts to identify selected regions.
From microscopes to microarrays: dissecting recurrent chromosomal rearrangements
Beverly S. Emanuel & Sulagna C. Saitta
p869 | doi:10.1038/nrg2136
Advances in technology and improved genome annotation have greatly clarified the role of genome architecture in the aetiology of many well-known and newly described clinical disorders. The authors focus on a group of genomic disorders mediated by segmental duplications to illustrate recent advances in their dissection and diagnosis.
Specialization and evolution of endogenous small RNA pathways
Elisabeth J. Chapman & James C. Carrington
p884 | doi:10.1038/nrg2179
Eukaryotes have evolved small RNA-guided regulatory networks to control RNA transcripts, chromatin, repeated genomic sequences and invasive agents, such as viruses. Spatiotemporal regulation of the transcriptome through these pathways has shaped the evolution of eukaryotic genomes and contributed to the complexity of multicellular organisms.
Perspective
Timeline
Opportunities for women in early genetics
Marsha L. Richmond
p897 | doi:10.1038/nrg2200
Although the early years of genetics have been well described by historians, it is only now being realized that this was one of the earliest emerging disciplines in twentieth-century biology to benefit from the contributions of women. Many, however, became 'silent scientists' — publishing no paper beyond their dissertation.
Correspondence
Correspondence: Semes for analysis of evolution: de Duve's peroxisomes and Meyer's hydrogenases in the sulphurous Proterozoic eon
Lynn Margulis, Michael Chapman & Michael F. Dolan
doi:10.1038/nrg2071-c1
Correspondence: Mutation rate variation in eukaryotes: evolutionary implications of site-specific mechanisms
D. G. King & Y. Kashi
doi:10.1038/nrg2158-c1
Correspondence: Reply to: Mutation rate variation in eukaryotes: evolutionary implications of site-specific mechanisms
Charles F. Baer, Michael M. Miyamoto & Dee R. Denver
doi:10.1038/nrg2158-c2
