Table of contents
August 2006 Vol 7 No 8
Research Highlights
Stem cells: Satellite cells shed light on asymmetrical DNA strand segregation | PDF (144 KB)
p586 | doi:10.1038/nrg1930
Technology: Microarray mix and match | PDF (173 KB)
p587 | doi:10.1038/nrg1932
Stem cells: Nanog: the gift of choice | PDF (106 KB)
p587 | doi:10.1038/nrg1934
Plant development: A TOPLESS two-step to polarity | PDF (100 KB)
p588 | doi:10.1038/nrg1926
Model organisms: Xenopus tropicalis goes genetic | PDF (146 KB)
p588 | doi:10.1038/nrg1931
In the news
A wellcome opportunity to invest | PDF (86 KB)
p588 | doi:10.1038/nrg1933
In brief
Developmental biology | Technology | Epigenetics | Genome biology | PDF (102 KB)
p589 | doi:10.1038/nrg1938
Technology: DNase I assay gets a face lift | PDF (559 KB)
p590 | doi:10.1038/nrg1927
Small RNAs: Silence of the P bodies | PDF (105 KB)
p590 | doi:10.1038/nrg1935
In brief
Computational genomics | Small RNAs | Human genetics | Plant evolution | PDF (98 KB)
p591 | doi:10.1038/nrg1939
Ethics watch
Cultivate bioethics! | PDF (95 KB)
p592 | doi:10.1038/nrg1928
Oncogenomics: Compare and contrast | PDF (133 KB)
p592 | doi:10.1038/nrg1936
Reviews
Standards for systems biology
Alvis Brazma, Maria Krestyaninova & Ugis Sarkans
p593 | doi:10.1038/nrg1922
Given the volume, complexity and heterogeneity of data generated by high-throughput approaches, modern biology needs standards for data representation and communication. But how should such standards be developed? What types of standard are needed and what determines whether they are successfully adopted by the community?
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
Jeffrey A. Engelman, Ji Luo & Lewis C. Cantley
p606 | doi:10.1038/nrg1879
Phosphatidylinositol 3-kinases (PI3Ks) are members of a unique and conserved family of intracellular lipid kinases that regulate a wide range of biological functions. Our understanding of the intricate regulation of this pathway is being applied to identify therapeutic strategies for diabetes and cancer.
The makings of maleness: towards an integrated view of male sexual development
Dagmar Wilhelm & Peter Koopman
p620 | doi:10.1038/nrg1903
In mammals, the SRY protein initiates the male developmental programme. This begins with testis determination and is followed by a network of transcriptional and endocrine signalling events in other organs. The authors review our current understanding of this process.
Highly parallel genomic assays
Jian-Bing Fan, Mark S. Chee & Kevin L. Gunderson
p632 | doi:10.1038/nrg1901
Fifteen years after the first generation of microarray platforms for highly parallel genomic analysis, intrinsically parallel whole-genome approaches to genotyping, epigenetic profiling and sequencing are being developed. What are the recent key developments that promise to transform the study of human health and disease?
Evolution on the X chromosome: unusual patterns and processes
Beatriz Vicoso & Brian Charlesworth
p645 | doi:10.1038/nrg1914
The sex chromosomes of mammals and Drosophila species are broadly similar, including in the forces that have shaped their independent evolution. Studying the basis of their differences, however, is informing our understanding of several population-genetic processes beyond eukaryotic-genome evolution.
Perspective
Timeline
The chromosome number in humans: a brief history
Stanley M. Gartler
p655 | doi:10.1038/nrg1917
Although genetics flourished in the first half of the twentieth century, human cytogenetics lagged behind, held up by the obstinate belief that humans had 48 chromosomes. This article examines the technical and psychological factors that hampered progress in the field.
Corrigendum: Genetic defects in the human glycome
Hudson H. Freeze
p660 | doi:10.1038/nrg1937
