Review
Nature Reviews Genetics 3, 299-309 (April 2002) | doi:10.1038/nrg777
There is a Correction (1 July 2002) associated with this article.
Patterns of linkage disequilibrium in the human genome
Kristin G. Ardlie1, Leonid Kruglyak2 & Mark Seielstad3 About the authors
Abstract
Particular alleles at neighbouring loci tend to be co-inherited. For tightly linked loci, this might lead to associations between alleles in the population — a property known as linkage disequilibrium (LD). LD has recently become the focus of intense study in the hope that it might facilitate the mapping of complex disease loci through whole-genome association studies. This approach depends crucially on the patterns of LD in the human genome. In this review, we draw on empirical studies in humans and Drosophila, as well as simulation studies, to assess the current state of knowledge about patterns of LD, and consider the implications for the use of LD as a mapping tool.
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Author affiliations
- Genomics Collaborative, 99 Erie Street, Cambridge, Massachusetts 02139, USA.
- Howard Hughes Medical Institute and Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4-100, Seattle, Washington 98109, USA.
- Program for Population Genetics, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA.
Correspondence to: Kristin G. Ardlie1 Email: kardlie@genomicsinc.com
Correspondence to: Leonid Kruglyak2 Email: leonid@fhcrc.org
Correspondence to: Mark Seielstad3 Email: mark@ppg.harvard.edu
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