Perspectives

Nature Reviews Genetics 11, 723-733 (October 2010) | doi:10.1038/nrg2878

ViewpointTen years of genetics and genomics: what have we achieved and where are we heading?

Edith Heard1, Sarah Tishkoff2, John A. Todd3, Marc Vidal4, Günter P. Wagner5, Jun Wang6, Detlef Weigel7 & Richard Young8  About the authors

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To celebrate the first 10 years of Nature Reviews Genetics, we asked eight leading researchers for their views on the key developments in genetics and genomics in the past decade and the prospects for the future. Their responses highlight the incredible changes that the field has seen, from the explosion of genomic data and the many possibilities it has opened up to the ability to reprogramme adult cells to pluripotency. The way ahead looks similarly exciting as we address questions such as how cells function as systems and how complex interactions among genetics, epigenetics and the environment combine to shape phenotypes.

Author affiliations

  1. Edith Heard is at the Mammalian Developmental Epigenetics Group, Unité de Génétique et Biologie du Dveloppement, INSERM U934/CNRS UMR3215, Institut Curie – Centre de Recherche, 26, rue d'Ulm, 75248 Paris Cedex 05, France.
    Email: Edith.Heard@curie.fr
  2. Sarah Tishkoff is at the Departments of Genetics and Biology, University of Pennsylvania School of Medicine, 428 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104-6145, USA.
    Email: tishkoff@mail.med.upenn.edu
  3. John A. Todd is at the Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.
    Email: john.todd@cimr.cam.ac.uk
  4. Marc Vidal is at the Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute; and the Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA.
    Email: marc_vidal@dfci.harvard.edu
  5. Günter P. Wagner is at the Yale Systems Biology Institute, Yale University, POB 208106, New Haven, Connecticut 06520-8106, USA.
    Email: gunter.wagner@yale.edu
  6. Jun Wang is at BGI-Shenzhen, Shenzhen 518083, China; and the Department of Biology, University of Copenhagen, Copenhagen DK-2200, Denmark.
    Email: wangj@genomics.org.cn
  7. Detlef Weigel is at the Department of Molecular Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tübingen, Germany.
    Email: weigel@weigelworld.org
  8. Richard Young is at the Whitehead Institute for Biomedical Research, MIT, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.
    Email: young@wi.mit.edu

Published online 7 September 2010

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