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Ten years of genetics and genomics: what have we achieved and where are we heading?

Nature Reviews Genetics volume 11, pages 723–733 (2010)Cite this article

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Abstract

To celebrate the first 10 years of Nature Reviews Genetics, we asked eight leading researchers for their views on the key developments in genetics and genomics in the past decade and the prospects for the future. Their responses highlight the incredible changes that the field has seen, from the explosion of genomic data and the many possibilities it has opened up to the ability to reprogramme adult cells to pluripotency. The way ahead looks similarly exciting as we address questions such as how cells function as systems and how complex interactions among genetics, epigenetics and the environment combine to shape phenotypes.

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Acknowledgements

S.T. thanks members of her laboratory for helpful discussions.J.A.T. thanks the Wellcome Trust, the Juvenile Diabetes Research Foundation International and the National Institute for Health Research Cambridge Biomedical Research Centre for funding, and J. Nadeau for sharing unpublished information. The Cambridge Institute for Medical Research is a recipient of a Wellcome Trust Strategic Award (079895). M.V. would like to thank M. Walhout, J. Dekker and J. Vandenhaute for helpful conversations on the subject discussed here.

Author information

Authors and Affiliations

  1. Edith Heard is at the Mammalian Developmental Epigenetics Group, Unité de Génétique et Biologie du Dveloppement, INSERM U934/CNRS UMR3215, Institut Curie – Centre de Recherche, 26, rue d'Ulm, 75248 Paris Cedex 05, France. Edith.Heard@curie.fr,

    Edith Heard

  2. Sarah Tishkoff is at the Departments of Genetics and Biology, University of Pennsylvania School of Medicine, 428 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104-6145, USA. tishkoff@mail.med.upenn.edu,

    Sarah Tishkoff

  3. John A. Todd is at the Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK. john.todd@cimr.cam.ac.uk,

    John A. Todd

  4. Marc Vidal is at the Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute; and the Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA. marc_vidal@dfci.harvard.edu,

    Marc Vidal

  5. and the Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA. marc_vidal@dfci.harvard.edu,

    Marc Vidal

  6. Günter P. Wagner is at the Yale Systems Biology Institute, Yale University, POB 208106, New Haven, Connecticut 06520-8106, USA. gunter.wagner@yale.edu,

    Günter P. Wagner

  7. China; and the Department of Biology, Jun Wang is at BGI-Shenzhen, Shenzhen 518083, University of Copenhagen, Copenhagen DK-2200, Denmark. wangj@genomics.org.cn,

    Jun Wang

  8. and the Department of Biology, University of Copenhagen, Copenhagen DK-2200, Denmark. wangj@genomics.org.cn,

    Jun Wang

  9. Detlef Weigel is at the Department of Molecular Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tübingen, Germany. weigel@weigelworld.org,

    Detlef Weigel

  10. Richard Young is at the Whitehead Institute for Biomedical Research, MIT, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA. young@wi.mit.edu,

    Richard Young

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  1. Edith Heard
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  2. Sarah Tishkoff
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Heard, E., Tishkoff, S., Todd, J. et al. Ten years of genetics and genomics: what have we achieved and where are we heading?. Nat Rev Genet 11, 723–733 (2010). https://doi.org/10.1038/nrg2878

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