Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
New guidelines from the American College of Sports Medicine and the American Diabetes Association provide specific exercise advice for individuals with type 2 diabetes mellitus, while new research emphasizes the importance of getting people off the couch and moving more often throughout the day.
The health responses to antenatal vitamin A supplementation evaluated in randomized intervention trials were recently systematically reviewed by van den Broek and colleagues. The importance of this update is reflected in the persistence of vitamin A deficiency during pregnancy and its potential to affect maternal and infant health and survival in many low-income countries.
With improved survival of patients with cystic fibrosis, a new management challenge is emerging—cystic fibrosis-related diabetes mellitus—but what aspects of the management of this disease are based on solid evidence? A new guideline takes steps towards providing the ultimate goal of a consistent and cogent management strategy.
A large-scale, placebo-controlled clinical study shows a remarkable benefit from adding exenatide, a short-acting GLP-1 receptor agonist, to insulin glargine, on a background of metformin and/or pioglitazone, in patients with type 2 diabetes mellitus. Is this partnership here to stay?
Up to one-third of patients treated with levothyroxine for primary hypothyroidism have biochemical evidence of inadequate thyroid hormone replacement. Could treatment effects of levothyoxine be optimized by bedtime administration on an empty stomach? A new study reveals the answer and also sheds light on other possible benefits of this alternative timing.
Environmental endocrine disrupting chemicals (EDCs) perturb reproductive development and function. Recent evidence suggests that developmental EDC exposures may disrupt the sexual differentiation of reproductive neuroendocrine systems through epigenetic programming of hypothalamic gene expression. This Review discusses endocrine disruption by four prototypical EDCs: vinclozolin, diethylstilbesterol, bisphenol A and polychlorinated biphenyls, and presents evidence for epigenetic modifications and transgenerational transmission of endocrine disrupted traits to future generations.
The growth of disseminated tumor metastases is a major cause of mortality in patients with cancer, and bone is a common site for metastasis. This Review summarizes the cellular and molecular components of the metastatic cascade and highlights potential new directions for future therapeutic strategies to target bone metastasis.
This Review discusses the genetic, prenatal and environmental antecedents of polycystic ovary syndrome. The reproductive, metabolic, cardiovascular, psychiatric and neoplastic complications of this common condition are presented, followed by a comprehensive discussion of diagnostic and therapeutic measures.
This Review highlights the interindividual and intraindividual variability of TSH levels and discusses the current controversy that surrounds the appropriateness of reference ranges defined on the basis of age, race, sex and amount of iodine intake. Moreover, the current evidence on lowering or increasing the upper limit of the TSH reference interval is reviewed and the need to individualize levothyroxine treatment in patients with elevated TSH levels is discussed.
Virilizing ovarian tumors are rare neoplasms that may affect both women of reproductive age and postmenopausal women. This Case Study describes a young woman with longstanding amenorrhea and virilization and highlights the challenges and pitfalls in the diagnosis and choice of proper treatment for this uncommon cause of female hyperandrogenism.
