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Diabetes

Should we treat infection or inflammation to prevent T2DM?

Nature Reviews Endocrinology volume 8, pages 323–325 (2012)Cite this article

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Infections have been proposed as triggers of inflammation that could predispose individuals to type 2 diabetes mellitus. In a prospective cohort study, Jeon and co-workers provide evidence of a role of Helicobacter pylori infection in the development of type 2 diabetes mellitus, but mechanistic insight is needed.

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Figure 1: Hypothetical model of the contribution of intestinal components, such as H. pylori infection, to the pathogenesis of type 2 diabetes mellitus (T2DM).

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Authors and Affiliations

  1. Department of Vaccination and Immune Protection, Immune Response Unit, National Institute for Health and Welfare, Biomedicum Helsinki, Haartmaninkatu 8, Helsinki, 00290, Finland

    Outi Vaarala

  2. Department of Medicine, University of Helsinki, Biomedicum Helsinki, Haartmaninkatu 8, Helsinki, 00290, Finland

    Hannele Yki-Järvinen

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  1. Outi Vaarala
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  2. Hannele Yki-Järvinen
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Correspondence to Outi Vaarala.

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Vaarala, O., Yki-Järvinen, H. Should we treat infection or inflammation to prevent T2DM?. Nat Rev Endocrinol 8, 323–325 (2012). https://doi.org/10.1038/nrendo.2012.31

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