Clinicians are responsible for selecting a suitable second-line treatment for patients with type 2 diabetes mellitus when metformin monotherapy fails. New evidence could aid clinicians in deciding between one of the most commonly used second-line agents, glimepiride, and the recently approved dipeptidyl peptidase 4 inhibitor linagliptin.
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Filip K. Knop declares that he has received speakers bureau from AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Eli Lilly, Merck, Sharp & Dohme, Novartis, Novo Nordisk and Ono Pharmaceuticals. Mikkel Christensen declares no competing interests.
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Christensen, M., Knop, F. Add-on to metformin in T2DM—linagliptin or glimepiride?. Nat Rev Endocrinol 8, 576–578 (2012). https://doi.org/10.1038/nrendo.2012.163
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DOI: https://doi.org/10.1038/nrendo.2012.163