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Diabetes

Cognitive decline and T2DM—a disconnect in the evidence?

Nature Reviews Endocrinology volume 10, pages 258–260 (2014)Cite this article

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Type 2 diabetes mellitus is associated with an increased risk of cognitive decline and dementia. Observational data suggest that hyperglycaemia, hypertension and dyslipidaemia might be involved in the causal pathway underlying this link, but data from the ACCORD MIND investigators challenge these findings. Why are the findings of observational and intervention studies so disconnected?

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Figure 1: Potential mediators of cognitive impairment in patients with type 2 diabetes mellitus.

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Authors and Affiliations

  1. Metabolic Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK

    Mark W. J. Strachan

  2. Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK

    Jacqueline F. Price

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  1. Mark W. J. Strachan
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  2. Jacqueline F. Price
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Correspondence to Mark W. J. Strachan.

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The authors declare no competing financial interests.

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Strachan, M., Price, J. Cognitive decline and T2DM—a disconnect in the evidence?. Nat Rev Endocrinol 10, 258–260 (2014). https://doi.org/10.1038/nrendo.2014.38

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