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Reproductive endocrinology

Hormone therapy to treat menopause—breaking a taboo

Findings from the Women's Health Initiative hormone study send the message that clinicians can feel confident prescribing menopausal hormone replacement therapy (MHT) to young menopausal women with moderate-to-severe symptoms who do not have absolute contraindications for hormone therapy. However, MHT is indicated for the alleviation of symptoms, not for chronic disease prevention.

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References

  1. Davis, S. R. et al. Understanding weight gain at menopause. Climacteric 15, 419–429 (2012).

    Article  CAS  Google Scholar 

  2. Rossouw, J. et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative Randomised Controlled Trial. JAMA 288, 321–333 (2002).

    Article  CAS  Google Scholar 

  3. Lobo, R. A. Where are we 10 years after the Women's Health Initiative? J. Clin. Endocrinol. Metab. 98, 1771–1780 (2013).

    Article  CAS  Google Scholar 

  4. Manson, J. E. et al. Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials. JAMA 310, 1353–1368 (2013).

    Article  CAS  Google Scholar 

  5. de Villiers, T. J. et al. Updated 2013 International Menopause Society recommendations on menopausal hormone therapy and preventive strategies for midlife health. Climacteric 16, 316–337 (2013).

    Article  CAS  Google Scholar 

  6. Geukes, M., van Aalst, M. P., Nauta, M. C. & Oosterhof, H. The impact of menopausal symptoms on work ability. Menopause 19, 278–282 (2012).

    Article  Google Scholar 

  7. Mishra, G. D. & Dobson, A. J. Using longitudinal profiles to characterize women's symptoms through midlife: results from a large prospective study. Menopause 19, 549–555 (2012).

    Article  Google Scholar 

  8. Connolly, B. S. et al. A meta-analysis of published literature on waist-to-hip ratio and risk of breast cancer. Nutr. Cancer 44, 127–138 (2002).

    Article  Google Scholar 

  9. Reeves, G. K. et al. Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study. BMJ 335, 1134 (2007).

    Article  Google Scholar 

  10. Stovall, D. W., Tanner-Kurtz, K. & Pinkerton, J. V. Tissue-selective estrogen complex bazedoxifene and conjugated estrogens for the treatment of menopausal vasomotor symptoms. Drugs 71, 1649–1657 (2011).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

S. R. Davis would like to acknowledge the support of an NHMRC research grant (grant number 1041853).

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Correspondence to Susan R. Davis.

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S. R. D. has received research grant support from Lawley Pharmaceuticals and is a consultant for Trimel Pharmaceuticals.

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Davis, S. Hormone therapy to treat menopause—breaking a taboo. Nat Rev Endocrinol 10, 6–8 (2014). https://doi.org/10.1038/nrendo.2013.219

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