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The association between cancer and a state of increased coagulability results in an elevated risk of venous thromboembolism (which includes deep vein thrombosis and pulmonary embolism), a severe co-morbidity that can lead to worsened survival.
This PrimeView highlights the mechanisms and pathophysiology of classic and exertional heatstroke and summarizes epidemiology, diagnosis and management. It accompanies the Primer on this topic by Bouchama and colleagues.
Heatstroke is a life-threatening illness typically associated with an uncontrolled rise in core body temperature and central nervous system dysfunction. This Primer describes its epidemiology, pathophysiology, diagnosis, preventive and therapeutic strategies, as well as long-term complications and areas for future research.
This PrimeView highlights the mechanisms underlying juvenile idiopathic arthritis, and summarizes the epidemiology, diagnosis and management of this disease. It accompanies the Primer on this topic by Martini and colleagues.
This Primer by Martini and colleagues summarizes the epidemiology, pathophysiology, diagnosis and management of Juvenile idiopathic arthritis (JIA), the most common chronic inflammatory rheumatic condition of childhood. In addition, this Primer discusses the quality of life of children with JIA and reviews future research directions to improve patient care.
Migraine is a common headache disorder. This Primer by Ferrari and colleagues summarizes the epidemiology, pathophysiology, diagnosis and treatment of migraine. Moreover, quality of life issues faced by patients with migraine and future research avenues are discussed.
This PrimeView highlights the mechanisms underlying the development of large-vessel vasculitis, and summarizes the epidemiology, diagnosis and management of this disease. It accompanies the Primer on this topic by Pugh and colleagues.
Large-vessel vasculitis is the most common primary vasculitis in adults, manifesting as inflammation of the aorta and its major branches. This Primer reviews the epidemiology, pathophysiology, diagnosis and management of this disease, highlights its effects on patient quality of life, and discusses future research questions.
