Browse Articles

Hypertensive eye disease (HED) refers to dieases of the eye that are associated with acute or chronic elevations in blood pressure. This Primer discusses the epidemiology, mechanisms, diagnosis and treatment of HED.

This PrimeView highlights the mechanisms of childhood stroke and accompanies the Primer article on childhood stroke by Wildgruber et al.

This Primer summarizes the mechanisms, epidemiology, diagnosis and treatment of stroke in children (that is, stroke occurring in those aged between 29 days and 18 years).

This PrimeView highlights the prothrombotic mechanisms associated with cancer that can lead to venous thromboembolism.

The association between cancer and a state of increased coagulability results in an elevated risk of venous thromboembolism (which includes deep vein thrombosis and pulmonary embolism), a severe co-morbidity that can lead to worsened survival.

Financial toxicity, that is, the negative effects of the economic burden of medical care, can lead to poor patient well-being and quality of life. Co-ordinated efforts by those involved in health care, supported by research into remedial approaches, are needed to ease the burden on patients.

This PrimeView highlights the mechanisms and pathophysiology of classic and exertional heatstroke and summarizes epidemiology, diagnosis and management. It accompanies the Primer on this topic by Bouchama and colleagues.

Heatstroke is a life-threatening illness typically associated with an uncontrolled rise in core body temperature and central nervous system dysfunction. This Primer describes its epidemiology, pathophysiology, diagnosis, preventive and therapeutic strategies, as well as long-term complications and areas for future research.

This PrimeView highlights the mechanisms underlying juvenile idiopathic arthritis, and summarizes the epidemiology, diagnosis and management of this disease. It accompanies the Primer on this topic by Martini and colleagues.

This Primer by Martini and colleagues summarizes the epidemiology, pathophysiology, diagnosis and management of Juvenile idiopathic arthritis (JIA), the most common chronic inflammatory rheumatic condition of childhood. In addition, this Primer discusses the quality of life of children with JIA and reviews future research directions to improve patient care.

This PrimeView highlights the diagnosis of migraine, a headache disorder that has a high global burden.

Migraine is a common headache disorder. This Primer by Ferrari and colleagues summarizes the epidemiology, pathophysiology, diagnosis and treatment of migraine. Moreover, quality of life issues faced by patients with migraine and future research avenues are discussed.

This PrimeView highlights the mechanisms underlying the development of large-vessel vasculitis, and summarizes the epidemiology, diagnosis and management of this disease. It accompanies the Primer on this topic by Pugh and colleagues.

Large-vessel vasculitis is the most common primary vasculitis in adults, manifesting as inflammation of the aorta and its major branches. This Primer reviews the epidemiology, pathophysiology, diagnosis and management of this disease, highlights its effects on patient quality of life, and discusses future research questions.

This PrimeView highlights the mechanisms and pathophysiology of peritoneal surface malignancies. It accompanies the Primer on this topic by Cortés-Guiral and colleagues.

Peritoneal surface malignancies have heterogeneous origins, including primary peritoneal tumours and metastases of other cancers, for example, digestive tract, reproductive tract, lung, breast and kidney tumours. This Primer reviews the epidemiology, mechanisms and diagnosis of these diseases, and discusses treatment options, patient quality of life and upcoming innovations.

This PrimeView highlights the diagnosis of endometrial cancer, and accompanies the Primer article on endometrial cancer by Makker and colleagues.

Climate change has multiple negative effects on global public health; reduced quality and quantity of crops result in increased food and financial insecurities leading to malnutrition (undernutrition and obesity) and diet-related non-communicable diseases, such as diabetes mellitus and cardiovascular diseases. In addition, food systems substantially contribute to greenhouse gas emissions and a shift towards sustainability is required to preserve human and planetary health.