Perspectives
Nature Reviews Drug Discovery 4, 249-255 (March 2005) | doi:10.1038/nrd1661
Article series: Model organisms
Innovation: Reporter mice and drug discovery and development
Adriana Maggi1 & Paolo Ciana1 About the authors
Abstract
In vivo reporter gene and imaging technologies have the potential to contribute to the drug discovery pipeline in several areas. They provide systems that enable the study of the biochemical activity of a target in disease, and in response to a drug, to be monitored over periods of time, and offer more accurate methods of measuring pharmacodynamics and toxicity. Although reporter-gene technology is in its infancy, with further refinement reporter animals could become a valuable tool in the early stages of target and lead identification and preclinical drug development.
Author affiliations
- Adriana Maggi and Paolo Ciana are at the Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy.
Correspondence to: Adriana Maggi1 Email: adriana.maggi@unimi.it
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