The VOICE study addressed the oncologist–patient dyad by adding a two-sided intervention. The results of this ostensibly positive study are, at best, limited and, at worst, cosmetic because clinically relevant long-term outcomes were unaffected. VOICE is the first attempt at addressing complexity in this genre of studies and, even with its shortcomings, teaches us some important lessons.
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Cherny, N. Lemonade from lemons: exploring the results of the VOICE study. Nat Rev Clin Oncol 14, 8–10 (2017). https://doi.org/10.1038/nrclinonc.2016.193
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DOI: https://doi.org/10.1038/nrclinonc.2016.193
