When a pregnant woman is diagnosed with cancer, clinical management is complicated by concerns about the possible detrimental effects of cancer treatments on pregnancy outcome and the health of the baby. Evidence about the outcomes of children after maternal chemotherapy for cancer during pregnancy is growing and we can say 'the kids are all right'.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Khöler, C. et al. How much platinum passes the placental barrier? Analysis of platinum applications in 21 patients with cervical cancer during pregnancy. Am. J. Obstet. Gynecol. http://dx.doi.org/10.1016/j.ajog.2015.02.022 (2015).
National Toxicology Program. NTP Monograph: Developmental effects and pregnancy outcomes associated with cancer chemotherapy use during pregnancy. NTP Monogr. 2, i-214 (2013).
Heinonen, K. et al. Late preterm birth and neurocognitive performance in late adulthood: a birth cohort study. Pediatrics http://dx.doi.org/10.1542/peds.2014-3556 (2015).
Shah, P. E., Robbins, N., Coelho, R. B. & Poehlmann, J. The paradox of prematurity: the behavioral vulnerability of late preterm infants and the cognitive susceptibility of very preterm infants at 36 months post-term. Infant Behav. Dev. 36, 50–62 (2013).
Sannia, A. et al. Different gestational ages and changing vulnerability of the premature brain. J. Matern. Fetal Neonatal Med. http://dx.doi.org/10.3109/14767058.2013.796166 (2013).
Cardonick, E. H., Gringlas, M. B., Hunter, K. & Greenspan, J. Development of children born to mothers with cancer during pregnancy: comparing in utero chemotherapy-exposed children with nonexposed controls. Am. J. Obstet. Gynecol. http://dx.doi.org/10.1016/j.ajog.2014.11.032 (2014).
Murthy, R. K. et al. Outcomes of children exposed in utero to chemotherapy for breast cancer. Breast Cancer Res. 16, 3414 (2014).
Amant, F. et al. Long-term cognitive and cardiac outcomes after prenatal exposure to chemotherapy in children aged 18 months or older: an observational study. Lancet Oncol. 13, 256–264 (2012).
Centers for Disease Control and Prevention. Birth Defects: Data & Statistics [online], (accessed 19 March 2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Peccatori, F., Corrado, G. & Fumagalli, M. After gestational chemotherapy, the kids are all right. Nat Rev Clin Oncol 12, 254–255 (2015). https://doi.org/10.1038/nrclinonc.2015.66
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrclinonc.2015.66