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Stroke after transcatheter aortic valve implantation (TAVI) is of major concern, with half of all events occurring days after the procedure. Amat-Santos and colleagues have reported a correlation between new-onset atrial fibrillation (NOAF) and 'delayed' cerebrovascular events in these patients and identified risk factors for this phenomenon, highlighting the need to rigorously address NOAF after TAVI.
Clinical trials of antihypertensive drugs typically last up to 5 years, but lifelong therapy for patients with hypertension is recommended in all treatment guidelines. To address this discrepancy, investigators from the Systolic Hypertension in the Elderly Program have published data from a 22-year follow-up showing sustained benefits of antihypertensive treatment.
In this state-of-the-art Review, Michele De Bonis and colleagues discuss the optimal management of patients with degenerative or function mitral regurgitation, from established surgical techniques to new percutaneous technologies. They also provide an overview of the use of echocardiography in the assessment of MR.
Understanding mechanisms of cardiac remodeling, with the goal of developing therapies to stop or reverse its progression, has become a major objective for investigators of heart failure. In this Review, Dr Koitabashi and Professor Kass discuss the evidence for 'reverse remodeling' by existing therapies, and review novel approaches that are currently moving from preclinical to clinical trials.
In the first of their two Reviews on cardiogenic shock in acute coronary syndromes, Stephen Westaby and colleagues discuss the evolving epidemiology of this condition, its clinical presentation, and predictors of outcome. They also explore the options for medical therapy and the potential role of therapeutic hypothermia in these patients.
Systems biology harnesses experimental and computational high-throughput techniques to unravel complex biological interactions, such as those between genetic and environmental factors. Drs MacLellan, Wang, and Lusis provide an overview of system-based approaches to cardiovascular diseases and discuss the translational implications of such studies.
