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Gene gating is the tethering of genes to nuclear pores to facilitate rapid nuclear export of transcripts. Scholz et al. show that gene gating of MYC increases nuclear export and overall expression of MYC transcripts in human colon cancer cells.
Moya et al. have uncovered a non-cell autonomous, tumour suppressive mechanism of competition driven by the Hippo pathway effectors YAP and TAZ in peritumoural hepatocytes that limits liver cancer in mice.
Lin et al. and Lambo et al. report in-depth therapeutic screening and genomic profiling, respectively, of two types of aggressive paediatric central nervous system tumours, and both groups identify vulnerabilities of these tumours that might be exploited therapeutically.
This Review discusses the PI3K–AKT signalling network and its control of cancer cell metabolism through both direct and indirect regulation of nutrient transport and metabolic enzymes, thereby connecting oncogenic signalling and metabolic reprogramming to support cancer cell survival and proliferation.
The majority of cancers arise in individuals over the age of 60. This Review discusses how ageing tissues through changes in the extracellular matrix as well as in the functions of fibroblasts and immune cells can impact tumour initiation, progression and response to therapy.
This Review discusses the role of bodily fluids and their underlying forces and imposed stresses in metastasis, highlighting the contributions of fluid mechanics to tumour cell intravasation, intravascular arrest and extravasation as well as to dissemination of tumour-derived factors.
This Review summarizes the epidemiology literature linking data-driven and investigator-defined dietary patterns to cancer risk, providing expert appraisal of new developments in the field and highlighting both emerging mechanistic insights and key areas for future research.
