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Several recent papers have shown that the miR-34 family of microRNAs is directly involved in mediating the effects of p53, indicating that non-coding RNAs have an important role in tumorigenesis. This Progress article discusses these papers and their implications.
Glioblastoma stem cells might be dependent on cues from aberrant vascular niches that mimic the normal neural stem cell niche. What are the implications of these findings for treatment of this disease?
Three major tumour-suppressor proteins have recently been shown to undergo monoubiquitylation-mediated nuclear–cytoplasmic shuttling. Can our increasing knowledge of this mechanism be used to treat cancer?
Several recent papers have shown that the Delta-like ligand 4 (Dll4)-Notch system restrains angiogenesis but, paradoxically, Dll4 inhibition decreases tumour growth. Is too much angiogenesis actually a good thing?