Current Issue
From the editors
p843 | doi:10.1038/nrc2770
Research Highlights
Tumour microenvironment: External influences | PDF (210 KB)
p845 | doi:10.1038/nrc2769
Cell migration: The benefit of being single | PDF (194 KB)
p846 | doi:10.1038/nrc2767
Pancreatic cancer: On your marks... | PDF (224 KB)
p846 | doi:10.1038/nrc2768
Signalling: A Ras and NF-
B pas de deux | PDF
(113 KB)
p847 | doi:10.1038/nrc2766
Reviews
Article series: MYC
The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics
Tracy A. Brooks & Laurence H. Hurley
p849 | doi:10.1038/nrc2733
Transcription-induced DNA supercoiling has dynamic effects on the MYC promoter element: it converts duplex DNA to non-duplex DNA structures. These non-duplex DNA structures regulate transcription and are amenable to small-molecule targeting. Does this represent another opportunity for the treatment of tumours?
Awakening guardian angels: drugging the p53 pathway
Christopher J. Brown, Sonia Lain, Chandra S. Verma, Alan R. Fersht & David P. Lane
p862 | doi:10.1038/nrc2763
The p53 pathway is deregulated in almost all tumours making it a prime target for new cancer drug development. This Review discusses the new approaches to drug discovery that are currently being used to target the p53 pathway and the progress made with the drugs that have been developed so far.
Mucins in cancer: function, prognosis and therapy
Donald W. Kufe
p874 | doi:10.1038/nrc2761
The mucin family of transmembrane and secreted glycoproteins form a barrier that protects the epithelium. Mucins affect epithelial polarity, inflammation, and cell growth and survival signalling; all of these functions could have roles in tumour formation and progression. This Review highlights the functions of mucins in cancer and discusses how these proteins are being targeted therapeutically.
Metabolism and cancer: the circadian clock connection
Saurabh Sahar & Paolo Sassone-Corsi
p886 | doi:10.1038/nrc2747
Evidence indicates that the disruption of the circadian clock might be directly linked to cancer. As described here, alterations in clock function could lead to aberrant cellular proliferation, DNA damage responses and altered metabolism.
Perspectives
Opinion
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
Sharad Kumar
p897 | doi:10.1038/nrc2745
Recent evidence suggests that caspase 2 may have multiple roles in the response to DNA damage, cell cycle regulation and tumour suppression. These findings are unexpected and have important implications for our understanding of tumorigenesis and the treatment of cancer.
