Abstract

The retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad range of paediatric and adult cancers, and a plethora of cellular functions and partners have been identified for the RB protein. Data from human tumours and studies from mouse models indicate that loss of RB function contributes to both cancer initiation and progression. However, we still do not know the identity of the cell types in which RB normally prevents cancer initiation in vivo, and the specific functions of RB that suppress distinct aspects of the tumorigenic process are poorly understood.

Author affiliations

1. Cancer Biology Program, Stanford University School of Medicine, Stanford, California 94305, USA.
2. Departments of Pediatrics and Genetics, Stanford University School of Medicine, 269 Campus Drive, Stanford, California 94305, USA.

Correspondence to: Julien Sage^1,2 Email: julsage@stanford.edu

Published online 24 July 2008

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