Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Metastasis

Preparing the soil

Nature Reviews Cancer volume 8, pages 832–833 (2008)Cite this article

Previous work by the authors showed that distant primary tumours induce the expression of the chemoattractants S100A8 and S100A9 in the lungs of mice, thereby recruiting MAC1+ myeloid cells. However, they also noted that conditioned medium from pre-metastatic lungs (lung conditioned medium, LCM) stimulated with S100A8 induced migration of MAC1+ myeloid cells more effectively than S100A8 alone, prompting them to search for other factors that might be involved downstream of S100A8.

One gene strongly upregulated in pre-metastatic lungs, serum amyloid A 3 (SAA3), had a pattern of expression similar to that of S100A8 and S100A9. Specifically, Saa3 was strongly expressed in MAC1+ myeloid cells and endothelial cells from mice bearing tumours formed by Lewis lung carcinoma (LLC) cells. The authors then showed that S100A8 induced Saa3 mRNA and secretion of SAA3 protein specifically in cultured lungs, but not in livers, and that SAA3 secretion could be blocked by a neutralizing S100A8 antibody. Similar results were found in vivo.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPER

  1. Hiratsuka, S. et al. The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase. Nature Cell Biol. 28 Sep 2008 (doi:10.1038/ncb1794)

    Article  CAS  Google Scholar 

Download references

Authors
  1. Sarah Seton-Rogers
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Seton-Rogers, S. Preparing the soil. Nat Rev Cancer 8, 832–833 (2008). https://doi.org/10.1038/nrc2525

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrc2525

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing