Review
Nature Reviews Cancer 7, 415-428 (June 2007) | doi:10.1038/nrc2131
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
Héctor Peinado1, David Olmeda1 & Amparo Cano1 About the authors
Abstract
The molecular mechanisms that underlie tumour progression are still poorly understood, but recently our knowledge of particular aspects of some of these processes has increased. Specifically, the identification of Snail, ZEB and some basic helix-loop-helix (bHLH) factors as inducers of epithelial–mesenchymal transition (EMT) and potent repressors of E-cadherin expression has opened new avenues of research with potential clinical implications.
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Author affiliations
- Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas 'Alberto Sols' CSIC-UAM, Arturo Duperier 4, 28029 Madrid, Spain.
Correspondence to: Amparo Cano1 Email: acano@iib.uam.es
Published online 17 May 2007
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