Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Several recent papers have shown that the Delta-like ligand 4 (Dll4)-Notch system restrains angiogenesis but, paradoxically, Dll4 inhibition decreases tumour growth. Is too much angiogenesis actually a good thing?
Although inhibition of tyrosine kinases has revolutionized cancer therapy, some of the inhibitors used have now been associated with cardiotoxicity. How does inhibition of cancer-relevant signalling pathways affect heart cells, and how can these effects be minimized?
Imatinib is a highly effective treatment for chronic myeloid leukaemia. However, patients often develop resistance to this ABL kinase inhibitor. This Review discusses second generation inhibitors of ABL and other signalling pathways that might help circumvent imatinib resistance.
Synthetic oleanane triterpenoids and rexinoids are two new classes of multifunctional drugs. Both classes of agents can prevent and treat cancer in experimental animals. What promise do they hold for cancer prevention and treatment in humans?
The basement membrane molecule laminin 332 (previously known as laminin 5) activates various signalling pathways and interacts with other basement membrane components to promote squamous-cell carcinoma (SCC) development. How does laminin 332 coordinate SCC tumorigenesis and can it be targeted therapeutically?
The peptidyl-prolyl isomerase PIN1 regulates a number of proteins important for cell-cycle progression, therefore it seems logical that alterations in PIN1 activity could be involved in tumorigenesis. But is loss or gain of function important?
This Timeline article provides a historical perspective on the generation of mouse models of breast cancer induced by ERBB2 (also known as HER2). What have these models taught us and how similar are they to human breast cancer?
