Table of contents
December 2007 Vol 7 No 12
From the editors
p889 | doi:10.1038/nrc2281
Research Highlights
Genomics: Combing the genome for cancer genes | PDF (339 KB)
p891 | doi:10.1038/nrc2279
Tumour profiling: Networking, protein style | PDF (497 KB)
p892 | doi:10.1038/nrc2277
Tumorigenesis: Taking an alternative route | PDF (556 KB)
p892 | doi:10.1038/nrc2278
In the news
A lean holiday season | PDF (73 KB)
p892 | doi:10.1038/nrc2286
Trial Watch
Specificity, sensitivity and cost | PDF (195 KB)
p893 | doi:10.1038/nrc2287
Leukaemia: A TALE of one Meis | PDF (232 KB)
p894 | doi:10.1038/nrc2280
Angiogenesis: Another target | PDF (321 KB)
p894 | doi:10.1038/nrc2283
In brief
Mathematical Models | Imaging | Cancer symptoms | Cancer stem cells | PDF (93 KB)
p895 | doi:10.1038/nrc2285
Tumour suppressors: WIP'ping up a storm | PDF (222 KB)
p896 | doi:10.1038/nrc2276
Therapeutics: It works, but how? | PDF (284 KB)
p897 | doi:10.1038/nrc2282
Tumour microenvironment: Inside moving out | PDF (172 KB)
p897 | doi:10.1038/nrc2284
Reviews
Roles of HMGA proteins in cancer
Alfredo Fusco & Monica Fedele
p899 | doi:10.1038/nrc2271
High mobility group A (HMGA) proteins alter chromatin structure and therefore affect the transcription of large sets of genes. This can contribute to both benign and malignant disease in several ways.
Oncogenes and tumour suppressors take on centrosomes
Kenji Fukasawa
p911 | doi:10.1038/nrc2249
Centrosomes have a crucial role in the formation of bipolar mitotic spindles, which are essential for accurate chromosome segregation. Certain oncogenic and tumour-suppressor proteins control centrosome duplication and function. How does their mutation result in numeral and functional centrosome abnormalities?
CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin?
Laurent Antoni, Nayanta Sodha, Ian Collins & Michelle D. Garrett
p925 | doi:10.1038/nrc2251
CHK2, an important player in the DNA-damage response signalling pathway, is a candidate multiorgan tumour susceptibility gene. Will the targeted modulation of this kinase or exploitation of its loss in tumours prove to be an effective anti-cancer strategy?
Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations
James D. Fackenthal & Olufunmilayo I. Olopade
p937 | doi:10.1038/nrc2054
Mutations in BRCA1 and BRCA2 are associated with cancer risk. However, it is important to understand the differences between populations, as both the prevalence of the mutations and the nature of their effects can differ between groups.
Innovations in image-guided radiotherapy
Dirk Verellen, Mark De Ridder, Nadine Linthout, Koen Tournel, Guy Soete & Guy Storme
p949 | doi:10.1038/nrc2288
How can image-guided radiotherapy be used to optimize radiotherapy doses to the tumour while sparing sensitive surrounding healthy tissue?
Perspectives
Opinion
Role of autophagy in cancer
Robin Mathew, Vassiliki Karantza-Wadsworth & Eileen White
p961 | doi:10.1038/nrc2254
Cells with defects in the autophagic pathway are sensitized to apoptosis in response to metabolic stress, but, paradoxically, autophagy defects are associated with increased tumorigenesis. How can this paradox be resolved?
Opinion
Cell-to-cell fusion as a link between viruses and cancer
Dominik Duelli & Yuri Lazebnik
p968 | doi:10.1038/nrc2272
The ability to fuse cells is shared by many viruses. Does cell fusion, by inducing chromosomal instability, for example, link more viruses to cancer development? How can such hypotheses be tested?
