Review
Nature Reviews Cancer 6, 193-203 (March 2006) | doi:10.1038/nrc1816
Infection, immune responses and the aetiology of childhood leukaemia
Mel Greaves1 About the author
Abstract
Childhood leukaemia is the principal subtype of paediatric cancer and, despite success in treatment, its causes remain enigmatic. A plethora of candidate environmental exposures have been proposed, but most lack a biological rationale or consistent epidemiological evidence. Although there might not be a single or exclusive cause, an abnormal immune response to common infection(s) has emerged as a plausible aetiological mechanism.
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Author affiliations
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The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, United Kingdom.
Email: mel.greaves@icr.ac.uk
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