Abstract

The low-molecular-weight range of the circulatory proteome is termed the 'peptidome', and could be a rich source of cancer-specific diagnostic information because it is a 'recording' of the cellular and extracellular enzymatic events that take place at the level of the cancer-tissue microenvironment. This new information archive seems to mainly exist in vivo, bound to high-abundance proteins such as albumin.Measuring panels of peptidome markers might be more sensitive and specific than conventional biomarker approaches. We discuss the advantages and disadvantages of various methods for studying the peptidome.

Author affiliations

1. Emanuel F. Petricoin, Robyn P. Araujo and Lance A. Liotta are at the Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas Virginia 20110, USA.
2. Claudio Belluco is at the Division of Surgical Oncology, CRO – IRCCS, National Cancer Institute, Aviano, Italy, and the Istituto Superiore di Sanità, Rome, Italy.

Correspondence to: Emanuel F. Petricoin¹ Email: epetrico@gmu.edu

Published online 9 November 2006

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