Review
Nature Reviews Cancer 5, 341-354 (May 2005) | doi:10.1038/nrc1609
There is a Correction (1 July 2005) associated with this article.
ERBB receptors and cancer: the complexity of targeted inhibitors
Nancy E. Hynes1 & Heidi A. Lane2 About the authors
Abstract
ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the expression or activation of epidermal growth factor receptor and ERBB2 are altered in many epithelial tumours, and clinical studies indicate that they have important roles in tumour aetiology and progression. Accordingly, these receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ERBB inhibitors are now used in the clinic. We will discuss the significance of these receptors as clinical targets, in particular the molecular mechanisms underlying response.
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Author affiliations
- Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.
- Novartis Institutes for BioMedical Research Basel, Oncology, K125.13.17, CH-4002 Basel, Switzerland.
Correspondence to: Nancy E. Hynes1 Email: Hynes@fmi.ch
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