Review
Nature Reviews Cancer 5, 275-284 (April 2005) | doi:10.1038/nrc1590
Tumour stem cells and drug resistance
Michael Dean1, Tito Fojo2 & Susan Bates2 About the authors
Abstract
The contribution of tumorigenic stem cells to haematopoietic cancers has been established for some time, and cells possessing stem-cell properties have been described in several solid tumours. Although chemotherapy kills most cells in a tumour, it is believed to leave tumour stem cells behind, which might be an important mechanism of resistance. For example, the ATP-binding cassette (ABC) drug transporters have been shown to protect cancer stem cells from chemotherapeutic agents. Gaining a better insight into the mechanisms of stem-cell resistance to chemotherapy might therefore lead to new therapeutic targets and better anticancer strategies.
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Author affiliations
- Laboratory of Genomic Diversity, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA.
- Cancer Therapeutics Branch, National Cancer Institute, Bethesda, Maryland, 20892, USA.
Correspondence to: Michael Dean1 Email: dean@ncifcrf.gov
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