Review
Nature Reviews Cancer 5, 263-274 (April 2005) | doi:10.1038/nrc1586
Immunosuppressive networks in the tumour environment and their therapeutic relevance
Weiping Zou1 About the author
Abstract
It is well known that many tumours are potentially immunogenic, as corroborated by the presence of tumour-specific immune responses in vivo. Nonetheless, spontaneous clearance of established tumours by endogenous immune mechanisms is rare. Therefore, the focus of most cancer immunotherapies is to supplement essential immunogenic elements to boost tumour-specific immunity. Why then has tumour immunotherapy resulted in a generally poor clinical efficiency? The reason might lie in the increasingly documented fact that tumours develop diverse strategies that escape tumour-specific immunity.
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Author affiliations
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Tulane University Health Sciences Center, Section of Hematology and Medical Oncology, 1430 Tulane Avenue New Orleans, Louisiana 70112-2699, USA.
Email: wzou@tulane.edu
Published online 18 March 2005
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