Review
Nature Reviews Cancer 5, 263-274 (April 2005) | doi:10.1038/nrc1586
Immunosuppressive networks in the tumour environment and their therapeutic relevance
Weiping Zou1 About the author
Abstract
It is well known that many tumours are potentially immunogenic, as corroborated by the presence of tumour-specific immune responses in vivo. Nonetheless, spontaneous clearance of established tumours by endogenous immune mechanisms is rare. Therefore, the focus of most cancer immunotherapies is to supplement essential immunogenic elements to boost tumour-specific immunity. Why then has tumour immunotherapy resulted in a generally poor clinical efficiency? The reason might lie in the increasingly documented fact that tumours develop diverse strategies that escape tumour-specific immunity.
- View At a Glance
Author affiliations
-
Tulane University Health Sciences Center, Section of Hematology and Medical Oncology, 1430 Tulane Avenue New Orleans, Louisiana 70112-2699, USA.
Email: wzou@tulane.edu
Published online 18 March 2005
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
TCR avidity: it's not how strong you make it, it's how you make it strongNature Immunology News and Views (01 Aug 2001)
Cancer vaccine strategies get bigger and betterNature Medicine News and Views (01 Oct 1999)
See all 4 matches for News And ViewsRESEARCH
Cerebral blood flow response in adenosine 2a receptor knockout mice during transient hypoxic hypoxiaJournal of Cerebral Blood Flow & Metabolism Original Article
Melanoma-specific expression in first-generation adenoviral vectors in vitro and in vivo ? use of the human tyrosinase promoter with human enhancersCancer Gene Therapy Original Article
See all 37 matches for Research