Review
Nature Reviews Cancer 3, 756-767 (October 2003) | doi:10.1038/nrc1186
The role of Notch in tumorigenesis: oncogene or tumour suppressor?
Freddy Radtke1 & Kenneth Raj2 About the authors
Abstract
Notch signalling participates in the development of multicellular organisms by maintaining the self-renewal potential of some tissues and inducing the differentiation of others. Involvement of Notch in cancer was first highlighted in human T-cell leukaemia, fuelling the notion that aberrant Notch signalling promotes tumorigenesis. However, there is mounting evidence that Notch signalling is not exclusively oncogenic. It can instead function as a tumour suppressor.
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Author affiliations
- Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland.
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Swiss Institute of Experimental Cancer Research (ISREC), Chemin des Boveresses 155, 1066 Epalinges, Switzerland.
Email: Freddy.Radtke@isrec.unil.ch
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