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The recent finding that the induction of cellular senescence is associated with the premalignant stages of tumour progression indicates that markers of senescence might prove to be useful diagnostic and prognostic tools. This article presents some of the more promising candidates.
Flow cytometry can be used to map signalling networks in individual cancer cells. This form of 'single-cell proteomics' can reveal important new information about the pathways that are activated in therapy-resistant cells and provide biomarkers for use in diagnosis and determining prognosis.
