Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Single-molecule detection

Breaking the concentration barrier

Nature Nanotechnology volume 8, pages 480–482 (2013)Cite this article

Subjects

The combination of a plasmonic nanoantenna and a nanoaperture has merged fluorescence enhancement and spatial confinement to enable single-molecule detection at biologically relevant concentrations.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Nanophotonic approaches to enhance single-molecule detection.

References

  1. Eid, J. et al. Science 323, 133–138 (2009).

    Article  CAS  Google Scholar 

  2. Punj, D. et al. Nature Nanotech. 8, 512–516 (2013).

    Article  CAS  Google Scholar 

  3. Levene, M. J. et al. Science 299, 682–686 (2003).

    Article  CAS  Google Scholar 

  4. Novotny, L. & van Hulst, N. Nature Photon. 5, 83–90 (2011).

    Article  CAS  Google Scholar 

  5. Kinkhabwala, A. et al. Nature Photon. 3, 654–657 (2009).

    Article  CAS  Google Scholar 

  6. Uemura, S. et al. Nature 464, 1012–1017 (2010).

    Article  CAS  Google Scholar 

  7. Acuna, G. P. et al. Science 338, 506–510 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Philip Tinnefeld is at the Institute for Physical and Theoretical Chemistry, TU Braunschweig, Braunschweig University of Technology, 38106 Braunschweig, Germany,

    Philip Tinnefeld

Authors
  1. Philip Tinnefeld
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Philip Tinnefeld.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tinnefeld, P. Breaking the concentration barrier. Nature Nanotech 8, 480–482 (2013). https://doi.org/10.1038/nnano.2013.122

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nnano.2013.122

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing