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Volume 7 Issue 12, December 2012

Unless specifically designed to avoid it, nanoparticles adsorb biomolecules from their surroundings when they enter the biological environment. This corona of biomolecules forms the identity of the nanoparticles because it is this surface that interacts with biological systems. The importance of this corona has been seen in biomaterial implants and cell scaffolds. However, unlike macroscopic surfaces, nanoparticles can travel to almost every part of the organism and further exchange biomolecules along its path. In the Review by Kenneth Dawson and co-workers, they discuss the basic concepts of this corona and how its properties may be linked to the biological behaviour of nanoparticles. Key issues are outlined for future research. The concept is illustrated on the cover that shows a corona on a nanoparticle surface interacting with a receptor protruding from the cell lipid bilayer.

Article p779

IMAGE: M.MONOPOLI, C. ÅBERG AND THE SCIENCE PICTURE COMPANY

COVER DESIGN: ALEX WING

Correction

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Editorial

  • We are changing our policy on when the received date of a manuscript is reset.

    Editorial
  • Corresponding authors should not neglect their responsibility to a journal or their co-authors.

    Editorial
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Correspondence

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Research Highlights

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News & Views

  • DNA can be used to create a very soft gel with liquid-like properties that can return to a preset solid shape when water is added.

    • Ju Li
    • Liyuan Bai
    News & Views
  • Magnetic circular dichroism on quantum dots doped with a small percentage of copper ions show the typical features of diluted magnetic semiconductors.

    • Jacek Kossut
    News & Views
  • Confinement of light in subnanometre gaps encounters a fundamental limit in the quantum tunnelling regime.

    • Niek F. van Hulst
    News & Views
  • Treatment of mammalian cells with dilute silicic acid followed by heating forms silica replicas of the cell template, offering a way to preserve cell specimens and generate biocomposites for various applications.

    • Jackie Y. Ying
    News & Views
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Review Article

  • Nanoparticles in contact with the biological environment adsorb a layer of biomolecules, which forms the biological identity of the particles. This Review outlines the concepts of the nanoparticle corona and how it interacts with biological systems, and assesses the critical problems to be resolved.

    • Marco P. Monopoli
    • Christoffer Åberg
    • Kenneth A. Dawson
    Review Article
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Letter

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Article

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Addendum

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Corrigendum

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