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Volume 5 Issue 11, November 2010

Small RNA molecules, called microRNAs, are important in various areas of biology but many of the methods used to detect them are time consuming or prone to error. Now Marija Drndić and co-workers have developed an electronic method for detecting picogram levels of rat liver microRNA. Collecting and analysing the microRNA from living tissue is a three-step process: first, an RNA probe complementary to the target microRNA sequence is added to the sample; next, the probe:microRNA duplex is enriched through binding to a viral protein; lastly, the abundance of the duplex is quantified using a nanopore. The performance of the detection system is improved by reducing the thickness of the membrane containing the nanopore and reducing the diameter of the nanopore itself.

Image credit: Robert R. Johnson

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  • This year's Nobel Prize in Physics can be seen as part of the larger story of hexagonally bonded carbon.

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  • It is essential to recognize the heterogeneous nature of 'the public' in engagement activities and to treat people as citizens rather than as mere laypersons, consumers or stakeholders.

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    • Ana Delgado
    • Kamilla Lein Kjølberg
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  • Solutions of DNA-based molecules can be taught to play a simple game in a process that does not require the operator to be familiar with the underlying molecular programming.

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