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Small RNA molecules, called microRNAs, are important in various areas of biology but many of the methods used to detect them are time consuming or prone to error. Now Marija Drndić and co-workers have developed an electronic method for detecting picogram levels of rat liver microRNA. Collecting and analysing the microRNA from living tissue is a three-step process: first, an RNA probe complementary to the target microRNA sequence is added to the sample; next, the probe:microRNA duplex is enriched through binding to a viral protein; lastly, the abundance of the duplex is quantified using a nanopore. The performance of the detection system is improved by reducing the thickness of the membrane containing the nanopore and reducing the diameter of the nanopore itself.
It is essential to recognize the heterogeneous nature of 'the public' in engagement activities and to treat people as citizens rather than as mere laypersons, consumers or stakeholders.
Ideas about angular momentum that have been borrowed from optics could allow the magnetic and spin structures of materials to be studied on atomic scales with electron vortex beams.
An atomic force microscope with antibodies attached to its tip can be used to determine methylation patterns in individual DNA strands by making hundreds of force spectroscopy measurements.
Solutions of DNA-based molecules can be taught to play a simple game in a process that does not require the operator to be familiar with the underlying molecular programming.
The unexpectedly low electron mobility in titania nanotubes is due to exciton-like trap states, rather than to grain boundaries or disorder as in other nanomaterials.
Superchiral electromagnetic fields can be used to detect adsorbed biomolecules at the picogram level and to probe their chiral supramolecular structure.
An atomic force microscope can measure the distances between 5-methylcytidine bases in individual DNA strands with a resolution of 4 Å, which should prove useful in studies of gene expression.
The magnetic state of a thin film of iron can be controlled by an electric field, demonstrating that high-density non-volatile information storage in metals is possible.
The replication of individual DNA templates catalysed by DNA polymerases at the orifice of an α-haemolysin nanopore allows the synthesis of DNA to be monitored in real time.
Confining gadolinium-based contrast agents inside the porous structure of silicon microparticles can improve their T1 contrast, offering a general approach for developing highly efficient MRI contrast agents.