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This Review summarizes mathematical modelling approaches that can be applied to microbiome datasets, providing insights into microbial dynamics and interactions in this complex system.
This Review describes recent findings on the biogenesis and the role of defective viral genomes during replication of RNA viruses and discusses their impact on viral dynamics and evolution.
This Review highlights some of the advances that have been made towards understanding the complexity of differential interferon (IFN) signalling inputs and outputs as well as some of the strategies viruses use to interfere with or circumvent IFN-induced antiviral responses.
This Review summarizes recent advances in our understanding of neutralizing antibody responses to enveloped viruses with different pathogenesis and discusses how this information is used to inform design of vaccines, therapeutics and diagnostics.
This Review describes the potential opportunities for finding new uses as antimicrobials for existing drugs, the approaches used for screening and the scientific, intellectual property and regulatory challenges to be overcome.
This Review Article describes how recent advances in viral genome sequencing and phylogenetics have enabled key issues associated with outbreak epidemiology to be more accurately addressed, and highlights the requirements and challenges for generating, sharing and using such data when tackling a viral outbreak.
Mosquitoes are responsible for transmission of important human diseases, including malaria, dengue and Zika. Here, Shaw and Catteruccia discuss how studying insect biology can inform the development of new control strategies against vector-borne disease.
This Review Article discusses the importance of considering known microbial processes to inform our understanding of the role of microbial communities in ecosystem processes, and a move away from approaches based solely on correlation analyses.
This Review Article discusses the role of bacteriophages in the marine environment, including interactions with their bacterial hosts and their impact on biogeochemical cycling, and a hypothesis to explain successional host–phage dynamics in marine systems.
This Review Article details various methods that can be used for phylogeny-aware analyses of microbiome datasets, together with online tutorials, including the considerations and challenges of each method depending on the research question.
G-protein-coupled receptors (GPCRs) enable fungi to sense and respond to their environment. The structure and function of fungal GPCRs are discussed, as well as their potential as targets for antifungal drug development.
In this Review Article, Horvath and Barrangou describe the discovery of CRISPR–Cas systems as mechanisms of adaptive immunity in prokaryotes and explore the technological applications that have emerged from studying these molecular machines.
This Review Article discusses the physical, chemical and ecological features of the phycosphere, the microenvironment surrounding individual phytoplankton cells, and its importance during phytoplankton–bacteria interactions in aquatic ecosystems.
This Review Article examines how microorganisms that have key roles in the ocean carbon and nitrogen cycles may respond to anthropogenic changes in the Earth's marine ecosystems.
A review of Bacteroides mechanisms for gut colonization and persistence, which may also serve as a framework to understand the biology of other microbiota species.
This Review describes the pro- and anti-carcinogenic roles played by the microbiota and highlights the therapeutic potential of microorganisms in tumourigenesis.
