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The soil bacterium Streptomyces iranensis triggers the production of natural products in the fungus Aspergillus nidulans using arginine-derived polyketide signalling molecules.
An alternative diaminopurine (Z) biosynthetic pathway using PurZ0 is found in bacteriophages and used for bacterial immune evasion, with higher structural and biochemical similarities to archaeal PurA than PurZ.
Genetics and biochemical reconstitution uncover the mechanism of bacterial teichoic acid d-alanylation. This mechanism, which relies on a conserved tyrosine motif, is widespread in other cell envelope polymer acylation pathways across bacteria.
HecRE is identified as a molecular switch regulating cyclic di-GMP levels and promoting binary cell states during Pseudomonas aeruginosa surface colonization and biofilm development.
Multiomics reveals that sexual differentiation in human malaria parasites, which is essential for transmission, is regulated by competition between phospholipid metabolism and histone methylation.
A conjugative plasmid isolated from Thermococcus enables interspecies transfer across Archaea, whether naturally competent or not, and at temperatures up to 100 °C.
Oil-rich deep-sea sediments are used to culture syntrophic communities of archaea and bacteria that pair petroleum alkane oxidation to sulfide generation.
The plant commensal Bacillus velezensis SQR9 uses its type VII secretion system to deliver effector protein YukE to plant roots, which causes iron leakage and promotes its colonization on roots.
Genomic and phenotypic analyses of 272 infant-associated Clostridium perfringens isolates suggest that pfoA is an important toxin gene in C. perfringens linked with preterm infant intestinal diseases.
Metadegradome sequencing maps 5′P mRNA decay intermediates in complex samples and 96 isolated bacterial species, to identify codon- and gene-level ribosome stalling responses to stress and drug treatment.
A suite of human monoclonal antibodies block infection by all human ACE2 binding sarbecoviruses, including severe acute respiratory syndrome coronavirus 2 variants, at subnanomolar concentrations in cell culture and protect mice against severe acute respiratory syndrome coronavirus 2 infection.
Personal information such as genetic sex, ancestry and clinically relevant genetic variants can be recovered from human reads present in faecal metagenomic sequencing data.
Analyses of metagenome-resolved genomes from humans and primate species reveal significant co-diversification of bacterial gut symbionts, which are becoming extinct from human populations.