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A combination of four phages engineered with a CRISPR–Cas payload can reduce the burden of Escherichia coli infections in animal models without inducing the host immune response.
Population genomics and functional validation show that a second parasite transporter, pfaat1, has a role in chloroquine resistance in Plasmodium falciparum.
An alternative diaminopurine (Z) biosynthetic pathway using PurZ0 is found in bacteriophages and used for bacterial immune evasion, with higher structural and biochemical similarities to archaeal PurA than PurZ.
Genetics and biochemical reconstitution uncover the mechanism of bacterial teichoic acid d-alanylation. This mechanism, which relies on a conserved tyrosine motif, is widespread in other cell envelope polymer acylation pathways across bacteria.
HecRE is identified as a molecular switch regulating cyclic di-GMP levels and promoting binary cell states during Pseudomonas aeruginosa surface colonization and biofilm development.
Multiomics reveals that sexual differentiation in human malaria parasites, which is essential for transmission, is regulated by competition between phospholipid metabolism and histone methylation.
A conjugative plasmid isolated from Thermococcus enables interspecies transfer across Archaea, whether naturally competent or not, and at temperatures up to 100 °C.
Many microorganisms remain understudied due to the challenges and complexities of culturing. An integrated lab automation and machine learning platform called BacterAI could be the future.
Oil-rich deep-sea sediments are used to culture syntrophic communities of archaea and bacteria that pair petroleum alkane oxidation to sulfide generation.
The plant commensal Bacillus velezensis SQR9 uses its type VII secretion system to deliver effector protein YukE to plant roots, which causes iron leakage and promotes its colonization on roots.
Systematic review and analysis of pre-pandemic coronavirus surveillance in bats identifies requirements for improvements to surveillance in the future.
Genomic and phenotypic analyses of 272 infant-associated Clostridium perfringens isolates suggest that pfoA is an important toxin gene in C. perfringens linked with preterm infant intestinal diseases.
A set of genes, including a lectin, two scavenger receptors and two actin regulators, were found to aid the early steps of coral–algal endosymbiosis, including algae recognition and uptake, in a Xenia soft coral species. The findings were made possible by using a combination of RNA interference-mediated gene knockdown, single-cell RNA sequencing (scRNA-seq), bioinformatics and cell biology approaches.