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Parasite biology

Two transporters enable chloroquine resistance in malaria

Population genomics and functional validation show that a second parasite transporter, pfaat1, has a role in chloroquine resistance in Plasmodium falciparum.

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Fig. 1: Temporal allele frequency change at single nucleotide polymorphisms coding for pfaat1 S258L and pfcrt K76T between 1984 and 2014.

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Correspondence to Carol Hopkins Sibley.

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Sibley, C.H. Two transporters enable chloroquine resistance in malaria. Nat Microbiol 8, 1193–1194 (2023). https://doi.org/10.1038/s41564-023-01414-x

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